Over $21,000 raised, thank you all so much!
We are so very grateful for everyone’s help and support in raising an amazing amount of over $21,000. We have now set a new challenge, let’s see if we can keep Darren’s Ride going and get it to $25,000. Every dollar we can raise is so vitally important to help fund research and to support others in their battle against MND. The smallest amount can make a big difference, please don’t forget donations over $2 are tax deductable, just go to http://darrensride.com.au/ and click the donate tab or button.
“There is a cure for MND, we just havent found it yet!”
Please share the word and keep watching for more Darren’s Ride events to come…
A huge thank you to Leeuwin Estate and the Leeuwin Carpark & Parking Crew for their incredibly generous donation of $1500 to Darren’s Ride, which has taken us to over $20,000 raised so far.
This money is so very important to help in the fight back against MND, by funding research as well as support services for others who are suffering. Further research is the only way that we can find the cause, treatments and ultimately a cure.
So please help us to continue Darren’s legacy, every dollar donated is tax deductable and will help us to get to a world free from MND. If you would like to join the Leeuwin team and get on board Darren’s ride,
By the supporting the Leeuwin concert series, you will enjoy a spectacular evening in a beautiful venue sipping fine wine, and allow other worthy causes and local charities to benefit from the hard work of the carpark crew as we have.
Go to https://leeuwinestate.com.au/concerts/ for details.
Once again, thank you, for Darren…
MND Research breaking news…new gene discoveries shed light on motor neurone disease…this is why your donations are so very important..
Breaking news from MND Australia – 27 June 2016
Two papers published today in the prestigious journal Nature Genetics provide new insights on the genes predisposing to amyotrophic lateral sclerosis (ALS), the most common form of motor neurone disease (MND). Three new genes known as C21orf2, MOBP and SCFD1 have been linked to MND, and a fourth gene, NEK1, has been confirmed as an MND susceptibility gene.
The findings are the result of a huge international effort involving hundreds of scientists and thousands of samples from people with MND. The work of the contributing groups was supported by various grants from governmental and charitable bodies, including the Motor Neurone Disease Research Institute of Australia.
The MNDRIA have prepared a brief explanation about what the latest research means;
This latest finding is a new piece of a complex puzzle. We already know that genetics plays an important role in why some people get MND. Research to date has told us about the genetics of some inherited forms of MND – where there’s a family history of the condition. Familial MND is seen in about 10% of all cases of MND, where more than one family member is affected. This new research has found several new genes associated with sporadic MND. Sporadic MND accounts for about 90% of people with MND, where only one person in a family has had MND. A combination of variations in the newly identified genes (plus other genes yet to be discovered) interacting with lifestyle and environmental factors could contribute to causing MND. Understanding what these new genes do could help to identify potential targets for therapies in the future.
New genes associated with sporadic MND
A study conducted by an international consortium of scientists has revealed three new genes known as C21orf2, MOBP and SCFD1are linked to ALS.
The C21orf2 gene was found to have rare mutations, which increased an individual’s risk of developing ALS by 65 per cent. The exact function of C21orf2 is unknown but it may be involved in cell movement, DNA repair and/or dysfunction of the structures that provide cells with energy.
Two other genes identified in the study MOBP and SCFD1 will require more extensive studies to fine-map variants in them that cause MND.
About 90% of ALS cases are sporadic. Project MinE was established in 2013 to find both common and rare DNA variations associated with ALS by mining genetic data (www.projectmine.com).
Using genetic information from Project MinE, comprising 15,156 ALS patients and 26,224 healthy controls from 15 countries, the researchers used “snapshot” chip-based genetic data combined with whole genome sequencing of 1,861 individuals to find new genes linked to ALS.
The Motor Neurone Disease Research Institute of Australia (MNDRIA) is funding the next phase of research through the Ice Bucket Challenge Grant awarded in 2015 to Professor Naomi Wray and colleagues for the establishment of the Sporadic ALS Australia (SALSA) consortium. The consortium has implemented identical data and DNA collection protocols in all the major MND clinics in Australia.
The Queensland Brain Institute’s Professor Naomi Wray was involved in the data analysis aspect of the international study.
“This research opens new opportunities to understand a complex and debilitating disease, which currently has no effective treatments.
“The SALSA consortium paves the way for Australians with MND to join international efforts in genetic discoveries as a step towards penetrating the complexity of this terrible disease,” Professor Wray said.
MNDRIA Executive Director Research Janet Nash said the collaborative efforts of researchers around the world, ALS patients and the public had provided vital insight to the mechanisms that lead to ALS.
“We are very hopeful that the discovery of new genes will lead to future therapeutic studies,” Ms Nash said.
New study confirms NEK1 is a risk gene for familial and sporadic motor neurone disease
An international study has confirmed that variants of the NEK1 gene confer susceptibility to ALS.
NEK1 was implicated in ALS in a study published in the journal Science in 2015 but required further investigation before being conclusively linked to the disease.
Researchers in the current study investigated more than 1,000 individuals from 11 countries including Australia with familial ALS (FALS) and more than 7,000 controls to reveal a significant association between FALS and gene variants that cause loss of function of the NEK1 protein.
Further analyses of sporadic ALS (SALS) cases and independent control cohorts confirmed significant disease association for a particular mutation “p.Arg261His” as well as NEK1 loss of function variants. In total, NEK1 variants were observed in nearly three per cent of ALS cases, demonstrating that it is a major risk factor for ALS.
NEK1 is a multi-functional enzyme that has been linked to several cellular functions including cell movement, DNA damage response and nerve cell morphology. Notably, NEK1 is thought to interact with the C21orf2 gene product, also identified as a risk factor for ALS in Nature Genetics today.
Article from MND Australia
Over $18,000 raised…Thank you all so much!!! A special merci to Michelle and the Blue Illusion Teams at
who raised an amazing $1834 from their first fashion event for Darren’s Ride. Thank you to all the retail therapists who participated!
Please help us keep Darren’s Ride going, remember all donations over $2 are fully tax deductible, and are so desperately needed to help other sufferers and to wipe out MND.
Start your engines…The Motor Neurone Disease Association of WA’s “MND Drive South West Adventure” is coming to town Friday 21 to Sunday 23 October 2016…Darren’s Ride is planning to be there, how about you?
How can you Bear not to have one of these?
Bears for Darren, handmade with love by Robin. So cute and cuddly, and they can even help you support your favourite footy team! Get one or a whole basket full; they are only $8 each. If you would like to find out how you can adopt one (or more), contact us here or through our Facebook page.
As always, all proceeds go to MNDAWA to fund research and care and support services for other families affected by MND.
Thank You, Thank You, Thank You . . .
Kirsten and her team at Darren’s Ride are so grateful to everyone who has donated and helped raise $15,000 for MND research and support for families affected by this awful disease.
Please remember that this money is just the start, we need to keep up the fundraising so that we can help pay for research to find a cure for MND.
MND paralyses the body leaving the mind intact in a majority of cases.
Motor Neurone Disease can be difficult to diagnose because the initial symptoms can be similar to many other diseases.
MND is non-discriminatory.
Each day in Australia – 2 people die from MND.
and 2 new people are diagnosed with MND.
Stay tuned for more events and functions throughout the year.
GARAGE SALE FOR DARREN’S RIDE
Robin McDonald and her golfing friends are organising a
Garage Sale for Darren’s Ride on Sunday 1st May at 2 Sicklemore Street, Booragoon, WA
commencing at 08:30AM.
There will be plenty of gifts and trinkets on offer, making it the perfect opportunity for you to find that special something for your mum, or yourself!
So be sure to drop in and spend up, as all proceeds will support MNDAWA and the Darren’s Ride campaign.